Opinions can be heard about the lack of "possibilities" of collagen penetration applied to the skin - to the cells of the dermis, and especially to the fibroblasts and keratinocytes that produce it in nature ...
There's been a misunderstanding. No one has ever claimed that high-molecular fish proteinonce... applied to the skin, penetrate the cells that naturally produce natural collagen of human skin.
First of all, it's not possible.
The transdermination mechanism of the Natural collagen it is based on something completely different. when it hits the five layers of the epidermis, the fish collagen coils are significantly broken down into amino acids that are structured in the same way as human collagen. and these are the same amino acids as in human collagenHydroxylisin, glycine, proline and hydroxyproline.
The latter is particularly remarkable because it is relatively easy to measure its amount in micrograms per kilometre on any test material, and it is no different from the case of comparative samples of the extracellular matrix (a gelatinous network of proteins and sugars that feel a frame function in the three layers of the skin: the dermis, the dermo-epidermal junction and the epidermis).
The extracellular matrix is composed mainly of water, collagen, elastin glycoproteins and carbohydrates, and its consistency and appearance is surprisingly similar to that of Natural Silver Collagen, after evaporating about two-thirds of the water...
Second... what for?
If you are trying to improve the collagen status of your skin - through a proper diet or by applying creams with active substances and vitamins in the carriers, or by using natural collagen - then you are promoting an increase in the amount of collagen in the extracellular matrix!
In this extracellular space, the collagen "factories", which are fibroblasts, chondrocytes and keratinocytes, release the polypeptides from the amino acids.
Only there, with the help of an activator that is ascorbic acid (vitamin C), are amino acid sequences formed in spirals (helixes) and we already know that they make it much more anxious when the extracellular matrix is supplied with a veritable rain of peptides from the disintegrated fish collagen spirals as it travels through the tight layers of the skin.
This is what the process of natural collagen transdermality looks like, explained in a simple way.
Today, this process can be tested in five ways:
- Through a tissue biopsy and a measurement of the amount of hydroxyproline before and after the application of the hydrated protein to the skin
- On the addition of radioisotopes to cosmetics and the monitoring of their migration in the body;
- In the observation of the reduction of T-cell suppressive activity in an in vitro culture with collagen
- Using the immunofluorescent staining method;
- By means of a densitometric determination of the percentage of peptides forming the so-called alpha chains in the product.
None of the critics of collagen express themselves through research because no one has done such research. Collagen protein is still an unexplored world of bio-organisms and quickly teaches humility to those who claim to know much about it. To date, not even all types and subtypes have been accurately described.
The triple helix of collagen "looks very much" like the spiral of human DNA and is more than mysterious to the genome, which is already quite well known: DNA is enchanted in cells and the super helix lives extra-cellularly.
So if you hear or read the following sentences: "Collagen, as a high molecular weight protein cannot penetrate the skin", "it is impossible for collagen to penetrate skin cells"and the like - then you should know that although they are correct from the point of view of logic, the formulation is not about the subject; they are carrying out polemics with the theses that nobody proclaims.
Natural collagen does not penetrate y does not have to penetrate the epidermisFor the stimulation of the reconstruction of the body's own collagen, it is absolutely sufficient that the torn peptide chains of hydroxylisin and hydroxyproline enrich the extracellular space of the skin's junction layer with the epidermis of the dermis as a result of the penetration of the fish protein coils into the epidermis.
In this process, relatively little happens in the cells, except for the initial phase of peptide formation, which is "squeezed" from the next cell anyway.
The procollagen produced in the extracellular space, in the fibroblasts, is then synthesized into helixes. So COLWAY's collagen doesn't have to penetrate the nucleus...
Collagen applied to the skin does not grow miraculously in our collagen fibers, it does not penetrate the skin as a whole, nor even inside the fibroblasts. No one has ever claimed it.
However, he enriches the extracellular matrix of all skin layers with amino acidswhich triggers a mechanism of increased fibroblast activity that has not yet been described clinically, so: an extra-Production from endogenous collagen through your system.
cosmetologists and dermatologists, the effect of Natural Collagen
purely from the outset, are basically based
in the books of those who have learned,
written in 100% in the 20th century.
There it was written until the late 1960s that collagen is not soluble in water (which of course is not true), until the late 1980s that it can have a spiral structure exclusively in the living organism (which is also not true) and until the late 1990s, and even later, that it is molecularly "too large" to move in the epidermis (which is also no longer true).
Simple immunological studies show how collagen particles are formed and then migrate to the skin's extracellular matrix, where peptides formed in keratinocytes are driven, by specific enzymes, to compounds of several hundred amino acid structures, all of which take place in the epidermal layer which, according to modern cosmetology, is "too dense" for high molecular weight proteins to travel there.
One of the serious companies on the Polish market until recently disseminated research from an EU SCCNFP programme, which showed that compounds with a molecular weight already above 1000, "get stuck" in the epidermis.
However, the development of biochemistry makes these theses ridiculous. well, the collagen produced in keratinocytes (i.e. in the epidermis) can move freely in the extracellular space. the same is true of the extracellular matrix of the skin's basement membrane.
The collagen hydrate of fish skin (Natural collagen) in the form of shaped spiral structures with a diameter of up to 1.4 nanometres, naturally penetrates into the extracellular space. their penetration into the epidermis and the epidermis-dermis junction layer in the extracellular matrix is today undisputed. no clinical studies are required. the thesis of the absolute tightness of the epidermis against water-soluble peptides can be proven today during student exercises with an electron microscope.
However, even today, doctors and cosmetologists are still unfamiliar with the concept of extracellular matrix and the perception of the objective fact of its existence in all layers of the skin, which is easier to find in the English language literature under the captivating term - extracellular matrix; abbreviation - ECM.