The collagen biosynthesis (also: collagenogenesis) is a complex process that includes both the stages that occur during the synthesis of all proteins and the unique stages that occur exclusively during the formation of collagen proteins. This process takes place in fibroblasts and chondrocytes, where the biosynthetic "production" of many different compounds and elements takes place in these cells.
This is where the components of the extracellular matrix of the dermis, enzyme molecules (signal molecules and others) and elements that complement the collagen and elastin fibres of the spleen are formed, among other things.
Cholagogenesis begins with the creation of a matrix of pro-collagen RNA from the ribonucleinsäuren (nuclear RNA) &ndash. With the help of this matrix, a synthesis of the polypeptides, the alpha chains, which normally consist of 100-350 amino acids, takes place in the cytoplasm of the nucleus of the fibroblasts or chondrocytes. The whole process depends on the presence of the respective enzymes, microelements such as iron and copper, but also on the presence of ascorbins (vitamin C).
Vitamin C is known for its positive effects on the body in general, and supplementation is already very common. Consumers are increasingly aware of the need to seek out natural, bio-organic forms of this vitamin, while avoiding cheap tablets containing industrially synthesized ascorbines that are poorly absorbed.
The main advantage of vitamin C is considered to be its positive effect on improving immunity, since, although it does not directly prevent infections, it significantly reduces the risk and shortens their duration.
Meanwhile, one of the most important tasks of vitamin C in the body is to support the synthesis of proteins, including collagenDue to the fact that the human body does not produce and store vitamin C, but obtains it from food, it is very important to ensure a sufficient amount in food and beverages. Possibly by supplementing the vitamin with naturally occurring vitamin C 100%.
Vitamin C deficiency not only blocks collagen synthesis, but also increases the risk of many diseases. Symptoms of extreme vitamin C deficiency, the disease known as scurvy, include numerous injuries to the skin, blood vessels, mucous membranes, gums, and even loss of teeth.
THE ROLE OF VITAMIN C
For the proper biosynthesis of collagen, an appropriate amount of vitamin C is required. In this case, the process of hydroxylation of proline and lysine (two new endogenous amino acids are formed: hydroxyproline and hydroxylysine) and the spiral of collagen (whose conformation is assumed by the molecules of the formed collagen) – creates correct and correspondingly strong bonds. Then the spirals are joined into a trio, and one speaks of a triple helix. About the tropo-collagen. It seems so, and without a treatment of the space around the fibroblasts with vitamin C, such processes do not occur or are extremely affected.
Vitamin C also has a great influence on the shape and final structure of all collagen fibres. And not only fibres. Collagen, the main component of connective tissue, is found throughout the body: bones, tendons, joints, skin, cornea, muscles and blood vessels. The right amount of collagen, and therefore indirectly also vitamin C, ensures rapid regeneration of damaged tissue, for example, accelerating the healing of wounds and fractures, absorbing bruises and bleeding, stopping bleeding and hemorrhaging, etc.
The undisputed advantage of vitamin C is its stimulating effect on the body's immune system. Nothing is more effective in stimulating the growth and efficiency of immune T and B cells and other white blood cells, whose function is to fight microbial diseases, than vitamin C. The proper functioning of the cardiovascular system, particularly the heart, also depends on the sufficient amount and bioavailability of vitamin C, which is supplied to the body. Vitamin C has a direct influence on the regulation of cholesterol production in the liver and its transformation into bile acids excreted by the body.